Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis
- 1 April 1991
- Vol. 13 (4), 157-161
- https://doi.org/10.1002/bies.950130403
Abstract
Titin, the largest protein identified to date (over 1 μm long, almost 3 million daltons in mass) is the third most abundant component of the sarcomere. In the mature myofibril, titin molecules span from M line to Z line, forming a third filament system which provides sarcomeric alignment and elastic recoil. In the developing sarcomere, accumulating evidence from studies both in vivo and in vitro implicates titin as part of a morphogenetic scaffolding, upon which critical events in myofibrillogenesis are coordinated in a time‐ and spacedependent manner.Keywords
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