Cannabis Abuse and the Course of Recent-Onset Schizophrenic Disorders
- 1 April 1994
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 51 (4), 273-279
- https://doi.org/10.1001/archpsyc.1994.03950040017002
Abstract
Objective: We sought to examine the relation between cannabis abuse and the symptomatic course of recent-onset schizophrenia and related disorders. Design: A prospective cohort study over a year using monthly Brief Psychiatric Rating Scale assessments. Participants: Cannabis-abusing patients (n=24) were compared with nonabusers (n=69). Eleven patients were mild and 13 were heavy cannabis-abusing patients. Results: Significantly more and earlier psychotic relapses occurred in the cannabis-abusing group (P=.03). This association became stronger when mild and heavy cannabis abuse were distinguished (P=.002). No confounding effect of other variables, eg, other street drugs, was found. In all but one patient, cannabis abuse preceded the onset of the first psychotic symptoms for at least 1 year. Conclusions: Cannabis abuse and particularly heavy abuse can be considered a stressor eliciting relapse in patients with schizophrenia and related disorders and possibly a premorbid precipitant.Keywords
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