α-Difluoromethylornithine-Induced Polyamine Depletion of 9L Tumor Cells Modifies Drug-Induced DNA Cross-Link Formation
- 9 December 1983
- journal article
- retracted article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 222 (4628), 1132-1135
- https://doi.org/10.1126/science.6417790
Abstract
Depletion of intracellular levels of polyamines, which are believed to have a role in the intranuclear stabilization of DNA, alters the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II in 9L rat brain tumor cells. Alkaline elution techniques were used to show that polyamine depletion alters the number of DNA cross-links formed by these cytotoxic agents.This publication has 16 references indexed in Scilit:
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