Variation in plasma prednisolone concentrations in renal transplant recipients given enteric-coated prednisolone.
- 9 June 1979
- Vol. 1 (6177), 1534-1536
- https://doi.org/10.1136/bmj.1.6177.1534
Abstract
Renal transplant recipients receiving intermittent haemodialysis and kept under normal ward conditions showed appreciable differences in plasma prednisolone concentrations after therapeutic doses of enteric-coated prednisolone tablets. This gross day-to-day variation occurred irrespective of the dosage used. Breakfast given before prednisolone tended to reduce the rate of absorption of the drug, the effect being quantitatively most pronounced with large doses. Haemodialysis had no apparent effect on the elimination of prednisolone from plasma. Such erratic blood concentrations of prednisolone as observed in these patients, possibly resulting from variable absorption, may be potentially hazardous. Hence use of enteric-coated tablets in renal transplant recipients should be viewed with caution.Keywords
This publication has 8 references indexed in Scilit:
- Plasma prednisolone levels from enteric and non-enteric coated tablets estimated by an original technique.British Journal of Clinical Pharmacology, 1977
- Plasma prednisolone levels in man following administration in plain and enteric-coated forms.British Journal of Clinical Pharmacology, 1977
- Effect of Hemodialysis on Methylprednisolone Plasma LevelsNephron, 1977
- Effect of Liquid Diet on Serum Protein Binding and Prednisolone Concentrations After Oral PrednisoneGastroenterology, 1976
- Kinetics and Interconversion of Prednisolone and Prednisone Studied with New RadioimmunoassaysJournal of Clinical Endocrinology & Metabolism, 1975
- Absorption of enteric and non-enteric coated prednisolone tablets.British Journal of Clinical Pharmacology, 1975
- Prevention of Peptic Ulceration During Corticosteroid TherapyBMJ, 1959
- DIFFERENCES IN METABOLISM OF PREDNISOLONE-C14AND CORTISOL-C14Journal of Clinical Endocrinology & Metabolism, 1957