Metabolic Fate of 11-Hydroxyandrostenedione-C14 in Human Subjects.

Abstract

Ll-Hydroxyandrostenedione-C14 was administered intravenously to 8 human subjects 2 normal males, 2 subjects with bile-fistulas, 3 females without and one female with cancer. The radioactivity was excreted in urine almost quantitatively within a very short period of time (8-12 hours). Only negligible amounts of radioactivity were found in the bile of the 2 subjects with bile-fistulas or in stools of all subjects. The unconjugated steroids were cleared from the plasma at 2 rates, a fast rate with a half-life of 30 minutes and a subsequent slower rate with a half-life of 80 minutes. The