Macrocyclic Design Strategies for Small, Stable Parallel β-Sheet Scaffolds
- 20 May 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 131 (23), 7970-7972
- https://doi.org/10.1021/ja902210f
Abstract
Pairs of short peptide strands can be induced to adopt an antiparallel β-sheet secondary structure in aqueous solution via a macrocyclic constraint, as illustrated by many natural and designed peptides. We show that an analogous strategy is successful for creation of small units of parallel β-sheet secondary structure in aqueous solution. Cyclization in this case requires nonpeptide segments for N-to-N and C-to-C interstrand linkage. Surprisingly, we find that only one of these segments needs to be preorganized.Keywords
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