POTENTIATION OF THE HYPERTENSIVE EFFECTS OF DESOXYCORTICOSTERONE ACETATE (DCA) BY VARIOUS SODIUM SALTS

Abstract

Renal function, blood pressure and plasma electrolytes were studied in rats which had been given desoxycorticosterone acetate (DCA) with various Na salts. The results indicate that the action of NaCl in intensifying the effects of DCA on these functions is specifically referable to the Na content. Phosphate was found to be exceedingly damaging to a kidney under the influence of DCA. The intensification of the renal damage caused by DCA and salts is not necessarily accompanied by an intensification of the hypertension. While the increase in blood pressure following the admn. of DCA antedates significant change in renal function, the presence of renal hypertrophy indicates that some renal change has occurred.