THE CLEARANCE OF INULIN AND SODIUM P-AMINOHIPPURATE IN THE RAT

Abstract

The manner in which inulin and PAH are handled by the normal rat kidney was investigated. This included a study of the relation of dose to plasma level, the plasma level-time response to the administered dose, the effect of moderate diuresis, and the relation of clearance to body wt. and surface area. As a result of these studies, a procedure was devised for the study of renal function in large groups of rats. The values obtained with this technique in the rat vary according to surface area. Expressed/100 cm2 of body surface the normal values are as follows: Cln 0.36 [plus or minus] 0.04 ml./min.; Cpah 2.31 [plus or minus] 0.18 ml./-min.; TMPAH.10 [plus or minus] 0.01 mg./min;. F. F. 15.7% [plus or minus] 2.3 and CpAH/TmpAH 22.1 [plus or minus] 2.0. Renal plasma flow/unit of tubular excretory tissue is greater than in other sp. so far investigated.