The deposition of Hg203-chlormerodrin in experimental brain tumors
- 1 September 1971
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 35 (3), 303-308
- https://doi.org/10.3171/jns.1971.35.3.0303
Abstract
The deposition of Hg203-chlormerodrin was studied in intracranial tumors in mice induced by implantation of 20-methyl cholanthrene by tissue assay, as well as light microscopic and electron microscopic autoradiography. The investigations were carried out in astrocytomas, glioblastomas, and meningeal tumors. The chlormerodrin content of the tumors exceeded that of normal brain with a significant tumor/brain ratio ranging from 5.8 to 22.5. It was found that the chlormerodrin molecule becomes rapidly incorporated in the tumor cells, with a preference for that portion of the cytoplasm associated with the vacuolar system.Keywords
This publication has 10 references indexed in Scilit:
- THE EXTRACELLULAR SPACE IN BRAIN TUMOURSBrain, 1970
- Vascular Invasion by Glioma Cells in Man: An Electron Microscopic StudyJournal of Neurosurgery, 1969
- Radioautographic Determination of Cellular Localization of Radioactive Mercury (203Hg) Chlormerodrin in Brain TumorsNew England Journal of Medicine, 1967
- Basic Aspects of Brain Tumor Localization by Radioactive SubstancesJournal of Neurosurgery, 1967
- Chlormerodrin Hg 203 and Electrolyte Distribution in Murine Brain TumorsArchives of Neurology, 1965
- Ultrastructural Changes in the Edematous Central Nervous SystemArchives of Neurology, 1965
- A Study of the Factors Responsible for the Accumulation of Radioactive Iodinated Human Serum Albumin (RIHSA) by Intracranial Tumours and Other LesionsJournal of Neurosurgery, 1965
- Localization of Radio-Iodinated Serum Albumin in Human GliomaArchives of Neurology, 1964
- HIGH-RESOLUTION AUTORADIOGRAPHYThe Journal of cell biology, 1962
- Human Brain Tumors: An Electron-Microscopic StudyJournal of Neurosurgery, 1962