Efficient Stereoselective Syntheses of Cyclic Amino Acids via Michael-Induced Ring-Closing Reactions
- 19 June 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (15), 2631-2633
- https://doi.org/10.1021/ol034777j
Abstract
[reaction: see text] Zn-chelated glycine ester enolates are highly efficient nucleophiles for the synthesis of trans-methoxycarbonylcyclopropyl- and cyclobutylglycines by domino sequences of Michael additions and subsequent ring closures. They react to give the anti isomers with high yields and excellent diastereoselectivities.Keywords
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