Mucormycotic infection in mice following prolonged incubation of sporesin vivoand the role of spore agglutinating antibodies on spore germination
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 22 (2), 101-108
- https://doi.org/10.1080/00362178485380171
Abstract
Following intranasal inoculation of mice, Rhizomucor pusillus spores are gradually cleared from the lung, with the clearance complete at 30 days. Incubation of R. pusillus spores in vivo for up to 14 days after intranasal inoculation resulted in pulmonary mucormycosis when the mice were then treated with cortisone. Spore-agglutinating IgM antibodies were detected in normal adult mice and R. pusillus-inoculated but not cortisone-treated mice. There was no correlation between antispore antibody titers and spore germination in vitro. The absence of germinated R. pusillus in inoculated but non-cortisone-treated mice appears to be due to a reversible inhibition of spore germination rather than destruction of spores by the host. The factor(s) that restrict spore germination are reversible and do not appear to be spore agglutinating antibodies. Sporen werden nach intranasaler Inokulation in Mäuse nach und nach aus der Lunge eliminiert, wobei die Eliminierung am 30. Tag vollendet ist. Inkubation von R. pusillus Sporen in vivo bis zu 14 Tage nach nasaler Applikation induziert eine Lungen-Mucormycose falls die Mäuse mit Cortison behandelt wurden. Sporenagglutinierende IgM-Antikörper wurden sowohl in normalen erwachsenen wie in R. pusillus inokulierten, aber nicht cortisonbehandelten Mäusen gefunden. Es bestand keine Korrelation zwischen den Antikörpern und Sporengermination in vivo. Die Abwesenheit von keimenden R. pusillus Sporen in inokulierten aber nicht cortisonbehandelten Mäusen scheint auf einer reversiblen Hemmung der Sporenkeimung und nicht auf einer Zerstörung durch den Wirt zu beruhen. Der Faktor (en), der die Sporenkeimung verhindert, ist reversibel aktiv und scheint nicht ein sporenagglutinierender Antikörper zu sein.This publication has 10 references indexed in Scilit:
- Murine model of pulmonary mucormycosis in cortisone-treated miceMedical Mycology, 1982
- Susceptibility of zygomycetes to human serumMedical Mycology, 1981
- Characterization of immunoglobulin classes of human antibodies to cryptococcus neoformansMycopathologia, 1977
- Experimental phycomycosis in mice; examination of the role of acquired immunity in resistance toAbsidia ramosaEpidemiology and Infection, 1976
- Glucocorticosteroid Therapy: Mechanisms of Action and Clinical ConsiderationsAnnals of Internal Medicine, 1976
- FACTORS DETERMINING THE SUSCEPTIBILITY OF MICE TO EXPERIMENTAL PHYCOMYCOSISJournal of Medical Microbiology, 1975
- How corticosteroids work*1, *2Journal of Allergy and Clinical Immunology, 1975
- An antifungal factor in human serumMedical Mycology, 1966
- The Germination of Sporangiospores of Rhizopus arrhizus; Spore Swelling and Germ-Tube EmergenceJournal of General Microbiology, 1964
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951