POLIOMYELITIS AS A COMPLEX INFECTION

Abstract

Young Cynomolgus mon-keys inoculated intracerebrally with an attenuated Type 1 polio virus and, after 5 days, with a monkey-adapted Coxsackie A-14 virus, frequently became paralyzed. Neither virus alone was capable of inducing paralysis. Similar results were observed when the AB IV strain of Coxsackie A-7 was substituted for the A-14 virus. In this case the 2nd inoculation was made intramuscularly. Paralytic poliomyelitis may at times represent the summation of two infections, the total of motor neuron destruction by two independent and non-interfering entero-viruses.