Secretin enhances [14C]erythritol clearance in unanesthetized dogs

Abstract

To determine the effect of secretin infusion on clearance of inert markers into bile, unanesthetized dogs fitted with Thomas cannulas received continuous infusions of [¹⁴C]erythritol and [³H]inulin throughout study. Taurocholic acid administered sequentially at 9.0, 20.0, and 40.0 μmol/min enhanced [¹⁴C]erythritol clearance, and GIH secretin (3 units/min) administered along with TCA (40.0μmol/min) increased [¹⁴C]erythritol clearance from 4.9±1.2 ml/10 min to 6.8±1.3 ml/10 min (P3H]inulin clearance was unaltered. Secretin alone also increased [¹⁴C]erythritol clearance but did not alter [³H]inulin clearance. The increase in [¹⁴C]erythritol clearance per unit increase in bile flow was less during secretin infusion than TCA. Thus, secretin increases [¹⁴C]erythritol transport through restricted channels, probably distal to the canaliculi. [¹⁴C]Erythritol may not be an accurate marker for canalicular bile flow in dogs during secretin infusion.