Deoxyribonucleoside Phosphorodithioates. Preparation of Dinucleoside Phosphorodithioates from Nucleoside Thiophosphoramidites.
- 1 January 1989
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 43 (9), 896-901
- https://doi.org/10.3891/acta.chem.scand.43-0896
Abstract
A series of protected thymidine thiophosphoramidites have been prepared and their properites evaluated. Although less reactive than phosphormadites, thiophosphoramidites with small N-substituents (methyl) are useful synthons for the preparation of nucleoside phosphorodithioates, as demonstrated by the preparation of a thymidine dimer. The coupling reactions are not as clean as those of the analogous phosphoramidites since the alkylthio group is somewhat labile.This publication has 6 references indexed in Scilit:
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