ORGANIC ACID-SOLUBLE PHOSPHORUS COMPOUNDS OF THE BLOOD

Abstract

"In this review attention is directed mainly to available information concerning the functions of the organic acid-soluble phosphorus compounds in mammalian bloods, and to changes in the conc. of these compounds in the blood observed in different conditions. The distribution of the phosphoric esters in normal blood varies greatly in different spp., and among normal individuals of a sp. the distribution may vary according to age, type of diet, and other factors. As non-diffusible anions in the cells, these compounds are important factors in the electrolyte equilibrium of the blood. Inasmuch as the phosphoric esters are synthesized and decomposed through reactions of the glycolytic cycle, the enzymatic processes of glycolysis have an important dynamic role in the maintenance of the electrolyte equilibrium of the blood. The greatest changes in conc. of organic acid-soluble P in the blood cells in pathologic conditions are usually in the diphosphoglycerate fraction, at least in human, dog, rabbit, and rat bloods, the spp. most studied. This fraction is decreased with P deficiency in rickets, and in various types of acidosis in subjects with adequate renal function, and increased after pyloric obstruction, after suppression of renal function, and in some other conditions. The significance of the changes in distr. of P in the blood in such conditions is discussed with regard to various metabolic disturbances, and to the state of the labile P reserves in the body.".