Characterization of the somatostatin-like immunoreactivity extracted from an adrenal medullary tumour
- 1 March 1982
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 2 (3), 147-154
- https://doi.org/10.1007/bf01116377
Abstract
Significant amounts of somatostatin-like immunor reactivity (SLI) were detected in the extract of a human catecholamine-secreting adrenal medullary tumour. After salt fractionation and reconstitution the major portion of SLI was purified by gel filtration and two HPLC steps; in all three systems it eluted in the position of somatostatin-14. The purified somatostatin-like peptide inhibited, in a dose-related manner, growth hormone release from stimulated perfused rat anterior pituitary ceils in vitro. Amino acid analysis showed the purified peptide to have an identical composition to somatostatin found in other species.This publication has 16 references indexed in Scilit:
- Primary structure of ovine hypothalamic somatostatin-28 and somatostatin-25.Proceedings of the National Academy of Sciences, 1980
- N‐terminally extended somatostatin: The primary structure of somatostatin‐28FEBS Letters, 1980
- Isolation and Characterization of Somatostatin from Anglerfish Pancreatic Islet*Endocrinology, 1979
- Higher molecular weight forms of immunoreactive somatostatin in mouse hypothalamic extracts: Evidence of processing in vitroProceedings of the National Academy of Sciences, 1979
- Enkephalin- and somatostatin-like immunoreactivities in human adrenal medulla and pheochromocytoma.Proceedings of the National Academy of Sciences, 1979
- Evidence for the Existence of a Biosynthetic Precursor for SomatostatinDiabetes, 1979
- Development and Validation of a Specific Radioimmunoassay for Somatostatin in Human PlasmaAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1979
- Perfused Rat Isolated Anterior Pituitary Cell Column as Bioassay for Factor(s) Controlling Release of Adrenocorticotropin: Validation of a TechniqueEndocrinology, 1978
- Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neuronsProceedings of the National Academy of Sciences, 1977
- Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth HormoneScience, 1973