Quantitative analysis of activation and inactivation of asymmetry currents in biological membranes, based on a conformational transition model
- 1 November 1978
- journal article
- research article
- Published by Springer Nature in The Journal of Membrane Biology
- Vol. 43 (2-3), 149-167
- https://doi.org/10.1007/bf01933476
Abstract
A basic voltage-dependent conformational transition mechanism is proposed. It comprises one relatively fast conversion between two individual states which are comparatively slowly coupled with a third state. Having introduced voltage as an additional parameter of state, standard methods of thermodynamics and rate theory are employed to describe the equilibrium and kinetic behavior of the system. In particular, a quantitative discussion is given regarding the asymmetrical displacement currents generated by switching on and off a voltage pulse. Effects of temperature pulse duration, and application of a conditioning prepulse are examined. The results provide a comprehensive basis for a quantitative analysis of pertinent experimental work. The so far presented measuring data can indeed be very well described along these lines.Keywords
This publication has 16 references indexed in Scilit:
- On the physico-chemical basis of voltage-dependent molecular gating mechanisms in biological membranesThe Journal of Membrane Biology, 1978
- CHEMICAL TRANSITIONS OF BIOPOLYMERS INDUCED BY AN ELECTRIC FIELD AND THEIR EFFECTS IN DIELECTRICS AND BIREFRINGENCE*Annals of the New York Academy of Sciences, 1977
- Inactivation of the sodium channel. I. Sodium current experiments.The Journal of general physiology, 1977
- Inactivation of the sodium channel. II. Gating current experiments.The Journal of general physiology, 1977
- IONIC CHANNELS AND GATING CURRENTS IN EXCITABLE MEMBRANESAnnual Review of Biophysics and Bioengineering, 1977
- Inactivation of the asymmetrical displacement current in giant axons of Loligo forbesi.The Journal of Physiology, 1977
- Kinetic properties and inactivation of the gating currents of sodium channels in squid axonPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1975
- Currents Related to Movement of the Gating Particles of the Sodium ChannelsNature, 1973
- The Fluid Mosaic Model of the Structure of Cell MembranesScience, 1972
- Kinetic Analysis by Chemical Relaxation MethodsReviews of Modern Physics, 1968