Early Effects of SV40 on Growth in vitro of Hamster and Human Tissue Cells.

Abstract

Summary Suspensions of cells derived from hamster embryonic and lung tissues soon after exposure to SV₄₀ virus exhibited enhanced capacity to multiply in a soft agar medium. Such enhancement was not observed in human kidney cells similarly treated. Production of SV₄₀ T antigen was seen in hamster embryo cells after 3-4 weeks and in human kidney cells after 8 weeks following exposure to the virus but was not observed at 3, 5 and 8 weeks in lung cells maintained under the same conditions.