Effect of Increasing the Extracellular Fluid Volume on the Arterial Blood Pressure of the Normal, Hypertensive and Nephrectomized Dog

Abstract

Marked expansion of the extracellular fluid volume results in relatively insignificant effects on the arterial blood pressure. Only in the nephrectomized dog in which the extracellular volume has been previously depleted does repair of this deficit result in an increase in the arterial blood pressure. In the presence of an overexpanded extracellular fluid volume or cardiac damage, the infusion of fluid results in a decline in blood pressure. The bearing of these expts. on the changes in arterial blood pressure noted in the nephrectomized dog are discussed.