Triazenes as Inhibitors of Mouse Sarcoma 180.

Abstract

3,3-Dimethyl-l-phenyltriazene possesses inhibitory activity for growth of the mouse tumor, sarcoma 180. Certain other triazenes have similar activity. Dimethyl-phenyltriazene produces comparable tumor inhibition whether given orally or intraperitoneally. The triazene induces the "waltzing" syndrome in the Swiss albino mouse used in this study. Nicotinic acid given prior to the triazene prevents the "waltzing" syndrome but does not modify tumor inhibition. In doses intoxicating to the Swiss mouse, the triazene is a moderate bone marrow depressant.