Catabolism of l-Arginine by Pseudomonas aeruginosa
- 1 February 1980
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 116 (2), 381-389
- https://doi.org/10.1099/00221287-116-2-381
Abstract
SUMMARY: Pseudomonas aeruginosa is known to break down arginine by the arginine deiminase pathway. An additional pathway has now been found whereby arginine is converted to putres-cine with agmatine and N-carbamoylputrescine as intermediates. The following enzyme activities belonging to this pathway were detected in crude extracts: arginine decarboxylase (EC 4.1.1.19), which catalyses the release of CO2 from arginine to give agmatine; agmatine deiminase (EC 3.5.3.12), which degrades agmatine to N-carbamoylputrescine; and N-carbamoylputrescine amidinohydrolase (EC 3.5.3.-), which then removes the ureido group of carbamoylputrescine. In crude extracts, arginine decarboxylase activity was stimulated by pyridoxal phosphate, Mg2+ and by the products of the catabolic pathway, putrescine and spermidine.This publication has 2 references indexed in Scilit: