Differential activity of allelic gamma-globulin genes in antibody-producing cells.
- 1 December 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 54 (6), 1765-1772
- https://doi.org/10.1073/pnas.54.6.1765
Abstract
In individual heterozygous mouse cells, the gamma-globulin allotype of secreted antibody to sheep red cells and of cyto-plasmic gamma-globulin was determined. It was found that of the 2 parental alleles determining allotype, one or the other is relatively active in individual cells, while its allele is relatively quiescent.Keywords
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