Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 2. Dihydro-10-oxofuro- and -thieno[3,2-c][1]benzoxepin-8-acetic acids
- 1 March 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (3), 456-458
- https://doi.org/10.1021/jm00213a028
Abstract
4,10-Dihydro-10-oxofuro[3,2-c][1]benzoxepin-8-acetic acid and 4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetic acid were evaluated in the carrageenan paw edema assay [in rats]. The thieno analogue was 10 times more active than the furano compound and 1.3 times more active than indomethacin. The therapeutic ratio (anti-inflammatory activity/gastric irritation liability) of the thieno analogue was 25 times that of indomethacin.This publication has 3 references indexed in Scilit:
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