Diagnostic significance of myeloperoxidase assay in neuronal ceroid‐lipofuscinoses (Batten‐Vogt syndrome)
- 1 September 1978
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 28 (9), 924
- https://doi.org/10.1212/wnl.28.9.924
Abstract
In 13 patients with morphologically established juvenile neuronal ceroid lipofuscinosis and 13 controls, the activity of leukocyte peroxidase (myeloperoxidase) was determined under various conditions: Measurement of water-soluble enzyme, the buffer-soluble enzyme, and the 1euk.ocyte homogenate; application of phosphate buffer (pH 7.0) and borate buffer (pH 7.6); employment of 9 mM, 28 mM, and 55 mM p-phenylenediamine as hydrogen donor; and measurement of the specific enzyme extinction at 10,60, and 180 seconds. A significant difference between mean values for patients and controls could not be established. In both groups, single individuals exhibited definitely increased or reduced enzyme concentrations, leaving us, however, without an adequate explanation for these observations. Our studies indicate that determination of myeloperoxidase has no value in establishing the diagnosis of neuronal ceroid-lipofuscinoses.This publication has 7 references indexed in Scilit:
- PEROXIDASE ACTIVITY IN THE PAROTID GLAND IN JUVENILE NEURONAL CEROID‐LIPOFUSCINOSISNeuropathology and Applied Neurobiology, 1977
- Isoelectric Enzyme Patterns of Leukocyte Peroxidase in Normal Controls and Patients with Neuronal Ceroid-LipofuscinosesNeuropediatrics, 1976
- Human leukocyte peroxidase: Activity of a soluble and membrane-bound enzyme form in normal persons and patients with neuronal ceroid-lipofuscinosisMetabolism, 1976
- Leukocyte peroxidase in Spielmeyer-Vogt's diseaseHuman Genetics, 1976
- Ultrastructural investigations of peripheral nerves in neuronal ceroid-lipofuscinoses (NCL)Zeitschrift für Neurologie, 1976
- Human saliva peroxidase: microanalytical isoelectric fractionation and properties in normal persons and in cases with neuronal ceroid-lipofuscinosisClinical Biochemistry, 1976
- Diagnosis of Gaucher's Disease and Niemann-Pick Disease with Small Samples of Venous BloodScience, 1967