STUDIES ON THE RENAL CONCENTRATING MECHANISM. II. EFFECT OF SMALL ACUTE CHANGES IN SOLUTE EXCRETION*
Open Access
- 1 January 1959
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 38 (1 Pt 1-2), 1-7
- https://doi.org/10.1172/jci103778
Abstract
The effect of small changes in osmolal clearance on the osmotic urine/plasma ratio achieved after 18 hours of water deprivation was studied in healthy men. Changes in osmolal clearance over the range of 0.9-5.1 ml/minute and in urine flow over the range of 0.24-1.71 ml/minute were observed in the resting state, after venesection, after light exercise and during mannitol and urea loading. The osmotic urine/plasma ratio was not constant. There was a significant inverse relationship between osmotic urine/plasma ratio and osmolal clearance at low rates of solute excretion and urine flow.Keywords
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