Effects of Rat Bile Infusion on Renal Function in Rats
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Kidney and Blood Pressure Research
- Vol. 13 (4), 213-222
- https://doi.org/10.1159/000173356
Abstract
The influence of rat bile infusion on renal function in rats and the possible role of bile-induced hemolysis in these effects were examined. The hemolytic action of rat bile and some bile salts were determined in vitro. After the i.v. infusion of rat bile (70 mg freeze-dried powder/2.55 ml) into pentobarbitone-anesthetized rats, the urine, sodium and potassium excretion rates were reduced more than half, which was due to the decrease of glomerular filtration rate and increase of tubular water and sodium reabsorption. A fall in blood pressure, a rise in hematocrit, and hemolysis were also found. Infusion of hemolysed (30 µl RBC) solution produced by distilled water and then made isotonic caused a short-duration increase in renal excretion and glomerular filtration rate, and the blood pressure was unchanged. Infusion of a rat bile-hemolysed solution after removal of bile acids with cholestyramine increased renal excretions at first with reduction thereafter. Infusion of the rat bile-hemolysed solution treated with barium sulfate produced a renal response very similar to rat bile alone. It is proposed that two factors are involved in the renal response after bile infusion, namely bile acid-induced hemolysis producing diuresis with natriuresis, and bile acid-induced antidiuresis and antinatriuresis, possibly due to a direct renal effect.Keywords
This publication has 9 references indexed in Scilit:
- Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the ratAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1985
- Effects of bile and bile salt infusions on renal function in dogsCanadian Journal of Physiology and Pharmacology, 1984
- The renal, cardiovascular and hemolytic actions in the rat of a toxic extract from the bile of the grass carp (Ctenopharyngodon idellus)Toxicon, 1984
- The Effect of Intrarenal Infusion of Bile on Kidney Function in the DogClinical Science, 1982
- EFFECT OF PROPRANOLOL ON RICINOLEIC ACID-INDUCED AND DEOXYCHOLIC ACID-INDUCED CHANGES OF INTESTINAL ELECTROLYTE MOVEMENT AND MUCOSAL PERMEABILITY - EVIDENCE AGAINST IMPORTANCE OF ALTERED PERMEABILITY IN PRODUCTION OF FLUID AND ELECTROLYTE ACCUMULATION1978
- Intrarenal mechanisms of salt retention after bile duct ligation in rats.JCI Insight, 1976
- Effect of Bile Infusion on the Dog KidneyNew England Journal of Medicine, 1966
- Hemolysis and augmentation of hemolysis by neutral steroids and bile acidsBiochemical Pharmacology, 1965
- ON THE TOXICITY OF PURIFIED BILE PREPARATIONSAmerican Journal of Physiology-Legacy Content, 1929