Cystine accumulation in cystinotic fibroblasts from free and protein-linked cystine but not cysteine
- 15 December 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 208 (3), 823-830
- https://doi.org/10.1042/bj2080823
Abstract
The accumulation of cystine in [human] cystinotic fibroblasts from free and protein-linked cystine was investigated. Cystine is not accumulated from cysteine but is readily accumulated from cystine. The accumulation from free cystine does not occur as a result of pinocytosis or from the degradation of a rapidly metabolized protein pool. Further studies of the degradation of S-S-containing proteins by these cells may aid understanding of the mechanisms of proteolysis.This publication has 17 references indexed in Scilit:
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