ANTIBODY-INDUCED KILLING INVIVO OF L1210-MTX-R CELLS QUANTITATED IN PASSIVELY IMMUNIZED MICE WITH IODODEOXYURIDINE-I-131-LABELED CELLS AND WHOLE-BODY MEASUREMENT OF RETAINED RADIOACTIVITY

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 117 (3), 822-829
Abstract
The killing of the LR subline of the DBA/2J leukemia L1210/MTX by passive antibody was followed in vivo with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity. The in vivo killing of LR cells was proportional to the in vitro 2-mercaptoethanol resistant [antibody] titer, independent of the complement system and radioresistant. Although a large percentage of the leukemic cells were killed in passively immunized mice, the protective effect of the passive antiserum was dependent on the active immune response of the host.