Neutralization of P blood group antibodies by synthetic solid‐phase antigens
- 6 May 1987
- journal article
- research article
- Published by Wiley in Transfusion
- Vol. 27 (3), 272-275
- https://doi.org/10.1046/j.1537-2995.1987.27387235638.x
Abstract
P blood group system antibodies are encountered frequently in clincal transfusion practice. The authors describe an improved method for removing P antibodies from patient specimens without dilution. Solid-phase synthetic P antigens were used to neutralize serums containing P blood group system antibodies; 26 alloantibodies with specificity other than P were not inhibited. The synthetic P antigens are also used to characterize the heterogeneous immunochemical fine specificity of antibodies to P1 and P+P1+Pk.This publication has 15 references indexed in Scilit:
- Artificial antigens. Antibody preparations for the localization of Lewis determinants in tissuesBiochemistry, 1981
- A Study of Soluble Lewis and P1 Substances Produced for Use in ImmunohematologyTransfusion, 1978
- Use of a Low‐Ionic‐Strength Medium in Manual Tests for Antibody DetectionTransfusion, 1976
- Structure of the human erythrocyte blood group P1 glycosphingolipidBiochemistry, 1975
- Properties of a synthetic antigen related to the human blood-group Lewis aJournal of the American Chemical Society, 1975
- Chemical synthesis of 2-acetamido-2-deoxy-4-O-(.alpha.-L-fucopyranosyl)-3-O-(.beta.-D-galactopyranosyl)-D-glucose. Lewis a blood-group antigenic determinantJournal of the American Chemical Society, 1975
- Human erythrocyte P and Pk blood group antigens: Identification as glycosphingolipidsBiochemical and Biophysical Research Communications, 1974
- The α‐Galactose Specificity of Anti‐PkVox Sanguinis, 1973
- Scoring of Hemagglutination ReactionsTransfusion, 1972
- Blood Group P Substance in Hydatid Cyst FluidsNature, 1957