Excitatory effects of kynurenine and its metabolites, amino acids and convulsants administered into brain ventricles: Differences between rats and mice
- 1 September 1982
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 54 (3-4), 229-238
- https://doi.org/10.1007/bf01254932
Abstract
When introduced intracerebroventricularly, quinolinic acid appeared to be the only kynurenine metabolite among those tested (L- and DL-kynurenine sulfate, kynurenic and nicotinic acids, nicotinamide) which induced locomotor excitement and clonic scizures in rats; in high dosage all exhibited convulsant action in mice. L-Kynurenine sulfate (500μg) induced continuous rotation in rats around a longitudinal axis in one or other direction. It also potentiated the convulsant effect of strychnine sulfate and caffeine. Neither the excitatory amino acids, L-glutamic and L-aspartic acids nor the inhibitory amino acids, GABA, glycine and taurine induced excitement or scizures in rats but did in mice. In rats, GABA, glycine and taurine induced sedation, side position and discoordination. The convulsants, strychnine sulfate and pentylenetetrazole, induced scizures both in rats and mice. Differences between species may derive from the better access of intracerebroventricularly administered drugs to mouse hippocampus. Thus mice may be preferable for studies of this type on excitatory amino acids (including kynurenine pathway metabolites) and rats for those on inhibitory amino acids.This publication has 7 references indexed in Scilit:
- Kynurenines and SeizuresEpilepsia, 1981
- ALTERATION OF THE ACTIVITY OF THE EPILEPTOGENIC FOCUS IN THE RAT HIPPOCAMPUS UNDER THE EFFECT OF THE MAIN TRYPTOPHAN-METABOLITES1981
- Effect of tryptophan metabolites on activity of the epileptogenic focus in the frog hippocampusJournal of Neural Transmission, 1980
- RELATIONSHIP BETWEEN PENTYLENETETRAZOL-INDUCED SEIZURES AND BRAIN PENTYLENETETRAZOL LEVELS IN MICE1980
- Relationship of brain monoamine and locomotor activity in ratsBiochemical Pharmacology, 1975
- Brain levels of metrazol determined with a new gas chromatographic procedureEuropean Journal of Pharmacology, 1971
- A Note on an Apparatus for Intracerebral Injections in Conscious Mice**Received November 2, 1959, from the Faculty of Pediatrics, Charles University, Prague, CzechoslovakiaJournal of the American Pharmaceutical Association (Scientific ed.), 1960