THE EFFECT OF AMINE OXIDASE INHIBITORS ON PREGNANCY

Abstract

SUMMARY: The effects of seven amine oxidase inhibitors on pregnancy were investigated in mice. Four of the compounds were derivatives of hydrazine and three were not. All the derivatives of hydrazine and one of the other compounds tested produced toxic effects in early pregnancy but were relatively inactive later. The effect of one of the compounds investigated (HP 1325) was, to a great extent, reversed by either progesterone or prolactin, suggesting an interference with the hormonal mechanism responsible for the maintenance of pregnancy. HP 1325 (and 5-hydroxytryptamine) did not interrupt pseudopregnancy, indicating that luteal function is not completely inhibited. Evidence is adduced that the effects on pregnancy are not related to any particular chemical structure or to the amine-oxidase activity of the compound tested.