Effect of Various Adrenal Steroids on Internal Fluid and Electrolyte Shifts of Fasted Adrenalectomized Dogs.

Abstract

Shifts of fluid and electrolytes from intra- to extracellular compartments follow intravenous injection of potent glucocorticoids in adrenalectomized dogs deprived of food and water during recovery from insufficiency. Aldosterone and desoxycorticosterone medication failed to improve symptoms, raise the lowered plasma volume or arterial pressure. Internal redistribution of water and electrolytes did not occur but renal retention of Na and Cl was evident.