HLA‐DR Expression on Cytotoxic T Lymphocytes

Abstract

A DR-null and DO-null mutant lymphoblastoid cell line (LCL) was used to generate cytotoxic T cells (CTL) to investigate DR expression on CTL. Effector T cells generated in human allogeneic mixed Ivmphocyte culture (MLC) were separated on a fluorescence-activated cell sorter (FACS) into DR-positive and DR-negative subsets. The great majority of delectable cytolytic activity, anti-class 1 and anti-class II (presumably anti-DP) CTL, as well as natural killer (NK)-like activity, resided within the DR-positive population.