Elaboration and Characterization of the Diazepam-Polyethyleneglycol 6000 Solid Dispersions
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 16 (15), 2283-2301
- https://doi.org/10.3109/03639049009043800
Abstract
Diazepam-polyethyleneglycol 6000 solid dispersions systems were prepared by melting and solvent methods. These dispersions were characterized using D.T.A., X-Ray diffraction and microscopy. The phase diagram has shown that this system is characterized as a simple eutectic mixture with a eutectic composition of 87% diazepam and 13% P.E.G. 6000. Solubility studies showed a linear increase in drug solubility with the increase of PE.G. 6000 concentration.Keywords
This publication has 5 references indexed in Scilit:
- The Aging of Solid Dispersion of Glybornuride in Polethylenglycol 6000Drug Development and Industrial Pharmacy, 1986
- Similarities in the release rates of different drugs from polyethylene glycol 6000 solid dispersionsJournal of Pharmacy and Pharmacology, 1985
- Evaluation of the Bioavailability of a Solid Dispersion of Phenytoin in Polyethylene Glycol 6000 and a Commercial Phenytoin Sodium Capsule in the DogJournal of Pharmaceutical Sciences, 1984
- Pharmaceutical Applications of Solid Dispersion SystemsJournal of Pharmaceutical Sciences, 1971
- Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man.CHEMICAL & PHARMACEUTICAL BULLETIN, 1961