Tallysomycin, a new antitumor antibiotic complex related to bleomycin. I. Production, isolation and properties.

Abstract

The unusual actinomycetes strain no. E465-94 produced a complex of new glycopeptide antibiotics, tallysomycin, which was separated by CM[carboxymethyl]-Sephadex chromatography into 2 major components, A (C68H107N21O27S2) and B (C62H95N19O26S2). They were isolated first in a Cu-chelated form and showed physicochemical properties similar to those of the bleomycin group of antibiotics. Tallysomycin exhibited broad antibacterial and antifungal activity, and was active in vivo against bacterial infections in mice. Tallysomycins A and B demonstrated potent activity in the prophage induction of lysogenic bacteria.