Anticortisol Action of 2-Methyl-9( )-Fluorocortisol.

Abstract

In adrenalectomized rats bearing a "granuloma pouch," it was shown that 10 [mu]g/day of 2-methyl-9(a)-fluorocortisol (Me-F-COL) definitely antagonizes the catabolic, antiphlogistic, thymolytic and splenic atrophy-producing actions of 400 [mu]g/day of cortisol acetate (COLA). Higher doses of Me-F-COL are less effective in these respects. Since Me-F-COL possesses some glucocorticoid potency, in addition to its ,strong mineralocorticoid effect, the comparatively low anticortisol activity of this compound, when it is given at high dose-levels, is in agreement with expectations based on the "law of intersecting dose-effect curves.".