Stimulation of Spermatogenesis by Gonadotropins in Men with Hypogonadotropic Hypogonadism
- 12 September 1985
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 313 (11), 651-655
- https://doi.org/10.1056/nejm198509123131102
Abstract
We evaluated the efficacy of gonadotropin treatment in stimulating spermatogenesis in men with hypogonadotropic hypogonadism. When 21 men with hypogonadotropic hypogonadism were treated with human chorionic gonadotropin, the sperm count increased to within the normal range in the 6 in whom hypogonadism had begun after puberty, but in only 1 of the 15 in whom it had begun before puberty (P<0.002). When the remaining 14 men with prepubertal hypogonadism were treated with human menopausal gonadotropin in addition to human chorionic gonadotropin, the sperm count increased to normal in 5 of the 7 who had not had cryptorchidism, but in only 1 of the 7 who had (P<0.05). The need for human menopausal gonadotropin as a replacement for follicle-stimulating hormone could not be predicted by pretreatment serum and urinary levels of follicle-stimulating hormone.This publication has 18 references indexed in Scilit:
- Restoration and Maintenance of Spermatogenesis by HCG Therapy in Patients with Hypothalamo-Hypophyseal DamageAndrologia, 2009
- Regulation of the pulsatile releases of luteinizing and follicle- stimulating hormones in ovariectomized hamstersBiology of Reproduction, 1984
- HYPERPROLACTINAEMIA AND HYPOGONADISM IN MEN: RESPONSE TO EXOGENOUS GONADOTROPHINSClinical Endocrinology, 1979
- MAINTENANCE OF SPERMATOGENESIS INDUCED BY HMG TREATMENT BY MEANS OF CONTINUOUS HCG TREATMENT IN HYPOGONADOTROPHIC MENActa Endocrinologica, 1978
- Gynecomastia and Semen Abnormalities Induced by Spironolactone in Normal MenJournal of Clinical Endocrinology & Metabolism, 1977
- Serum LH and FSH Responses to Synthetic Gonadotropin-Releasing Hormone in Normal MenJournal of Clinical Endocrinology & Metabolism, 1975
- Successful Gonadotropin Therapy of Infertility in a Hypopituitary ManArchives of Internal Medicine, 1970
- Effect of Gonadotropins on the Recovery of Spermatogenesis in Hypophysectomized PatientsJournal of Clinical Endocrinology & Metabolism, 1969
- Effects of Human Menopausal Gonadotrophin on a Eunuchoidal MaleNew England Journal of Medicine, 1966
- The Restoration of Human Spermatogenesis and of the Reproductive Tract with Urinary Gonadotropins Following HypophysectomyFertility and Sterility, 1966