Experimental Urolithiasis III. Prevention and Dissolution of Calculi by Alteration of Urinary pH
- 1 July 1951
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 66 (1), 1-5
- https://doi.org/10.1016/s0022-5347(17)74306-6
Abstract
The influence of urinary pH on exptl. calculi was tested in rats with 2 types of expts. The stimulus to stone formation was a foreign body surgically implanted into the bladder. NH4CI added to the diet was used to lower the urinary pH. In one expt. the addition of NH4CI prevented the formation of calculi in all of 21 animals. In the 2d experiment where acidification was begun only after stones had already formed, complete dissolution of the calculi occurred in 14 or 20 animals. Suitable control groups accompanied each expt.Keywords
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