Antiviral Activity of Polyribocytidylic Acid in Cells Primed with Polyriboinosinic Acid
- 16 July 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 173 (3993), 260-262
- https://doi.org/10.1126/science.173.3993.260
Abstract
Separate administration of polyribocytidylic acid [poly(rC)] and polyriboinosinic acid [poly(rI)] to cell cultures in vitro resulted in an antiviral activity identical to or greater than that resulting from addition of the poly(rI) • poly(rC) complex. Priming of cells with poly(rI), followed by treatment with poly(rC), gave a consistently greater antiviral activity than poly(rI) • poly(rC) itself. This priming effect was obtained in several cell cultures challenged with different viruses. In vivo, the antiviral activity of poly(rI) • poly(rC) was only partially restored if poly(rI) and poly(rC) were injected separately; prior injection of poly(rI) proved superior in restoring this antiviral activity as compared to prior injection of poly(rC).Keywords
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