RATE OF ENTRANCE OF URATE AND ALLANTOIN INTO THE CEREBROSPINAL FLUID OF THE DALMATIAN AND NON-DALMATIAN DOG

Abstract

The allantoin and urate concns. in plasma and cerebrospinal fluid of 19 non-Dalmatian and 2 Dalmatian dogs were detd. before and after intraven. injn. of each substance, and before and after injn. of urate into the cerebrospinal fluid. Creatinine and allantoin detns. were performed on the plasma and cerebrospinal fluid of 2 nephrectomized non-Dalmatian dogs. The results indicate that some selective hindrance exists to the passage of both urate and allantoin from the plasma to cerebrospinal fluid of Dalmatian dogs, and a similar hindrance exists to the passage of allantoin and of injd. urate from the plasma to the C.S.F. of non-Dalmatian dogs.