PhenylethanolamineN-methyltransferase from the brain and adrenal medulla of the rat
- 1 December 1978
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 3 (6), 755-762
- https://doi.org/10.1007/bf00965998
Abstract
Two different molecular forms of phenylethanolamineN-methyltransferase (PNMT, EC 2.1.1) have been isolated from the brain and adrenal glands of the rat as indicated by certain of their physicochemical properties, such as: molecular weight estimated on the basis of gel chromatography of Sephadex G-100; pH optima; electrophoretic mobility on acrylamide gel; and steady-state kinetic parameters. The highK m value for the brain PNMT has been assumed to be responsible for the low methylation ratio between norepinephrine and epinephrine in the CNS.Keywords
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