Regional distribution of ethanol in the rat brain
- 1 December 1978
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 56 (6), 988-992
- https://doi.org/10.1139/y78-157
Abstract
The regional distribution of ethanol in selected areas of the rat brain was studied after single intravenous and intraperitoneal injections. Ethanol concentrations (measured by gas–liquid chromatography) in cortex, striatum, and hippocampus were compared with arterial and venous blood alcohol concentrations.As previously reported, equilibrium between tissue and arterial blood occurred within 3 min and followed simple diffusion kinetics. At shorter time intervals (1 min) after injection, regional ethanol concentrations differed, possibly because of regional blood flow and tissue mass. Equilibrium between tissue and venous blood required 10–15 min and coincided with the disappearance of the arterial–venous difference.These findings suggest that tissue ethanol concentrations cannot be determined from venous blood samples until brain arteriovenous equilibrium has occurred. They also support the argument that alcohol concentrations in tissue perfusates do not necessarily provide a reliable guide to those in the tissue.This publication has 10 references indexed in Scilit:
- Regional distribution of ethanol in rat brainLife Sciences, 1976
- Microdetermination of alcohol in blood by gas–liquid chromatographyCanadian Journal of Physiology and Pharmacology, 1968
- EFFECTS OF CHRONIC INTAKE OF ETHANOL ON RATE OF ETHANOL METABOLISMCanadian Journal of Physiology and Pharmacology, 1966
- ACUTE EFFECTS OF ETHANOL ON TISSUE ELECTROLYTES IN THE RATCanadian Journal of Physiology and Pharmacology, 1966
- The Permeability of Brain Capillaries to Non‐ElectrolytesActa Physiologica Scandinavica, 1965
- INFLUENCE OF CHLORPROMAZINE AND ALCOHOL ON CEREBRAL HEMODYNAMICS AND METABOLISMThe American Journal of the Medical Sciences, 1955
- EFFECTS OF ETHYL ALCOHOL ON CEREBRAL BLOOD FLOW AND METABOLISMJAMA, 1953
- Potentiation of the Depressant Action of Alcohol by AdrenalinQuarterly Journal of Studies on Alcohol, 1946
- Alcohol and Cerebral VasodilatationNew England Journal of Medicine, 1942
- Determination of the metabolic rate of alcoholThe Journal of Physiology, 1940