Clinicopathologic and therapeutic aspects of angioimmunoblastic lymphadenopathy‐related lesions
Open Access
- 1 March 1992
- Vol. 69 (5), 1259-1267
- https://doi.org/10.1002/cncr.2820690531
Abstract
The clinicopathologic features of 14 patients with angioimmunoblastic lymphadenopathy (AIL)‐related lesions were analyzed. Lymph node biopsy specimens from all the patients showed a diffuse obliteration of lymph node architecture, prominent vascular proliferation, a polymorphous cellular infiltrate, including immuno‐blasts, and varying degrees of clear cell proliferation. The patients were eight males and six females, with a median age of 58.5 years. All but one were in an advanced stage at the time of diagnosis. Bone marrow involvement was observed in eight patients. Thirteen patients had a negative serologic reaction for antibody to human T‐cell leukemia virus type I (HTLV‐I), and one patient was considered to be a HTLV‐I carrier. Polyclonal hypergammaglobulinemia was observed in 6 patients, and 6 of the 12 patients showed elevated IgE levels. Immunophenotyping of the involved lymph nodes revealed a preponderance of T‐cells in all the patients. Eleven of these patients showed a predominance of CD4+ over CD8+ T‐cells, and only one patient showed a predominance of CD8+ over CD4+ T‐cells. Two of five patients whose gene analysis was carried out showed clonal rearrangement of the T‐cell receptor beta chain gene without rearrangement of the immunoglobulin heavy chain genes. Twelve patients received doxorubicin‐containing combination chemo therapy; of these, 7 patients achieved complete response, and the other 5 had partial response. Nine patients are still alive with a median follow‐up period of 21 months, and five patients died during the follow‐up period. Progression to high‐grade T‐cell lymphoma with systemic infiltration was ascertained in two of three cases for which autopsy was performed. From our experience, we recommend doxorubicin‐containing combination chemotherapy as initial therapy for AIL‐related lesions.Keywords
This publication has 30 references indexed in Scilit:
- Diagnostic and prognostic value of monoclonal antibodies in immunophenotyping of angioimmunoblastic lymphadenopathy/lymphogranulomatosis XBritish Journal of Haematology, 1987
- Evidence for monoclonal T lymphocyte proliferation in angioimmunoblastic lymphadenopathy.Journal of Clinical Pathology, 1986
- Angioimmunoblastic lymphadenopathyAmerican Journal of Hematology, 1985
- Study of the Natural History of Immunoblastic Lymphadenopathy and Atypical Immunoproliferative DisordersCancer Investigation, 1983
- Lymphoma of Cytotoxic/Suppressor T Cell Phenotype (T8) following Angioimmunoblastic LymphadenopathyOncology, 1983
- Case 30-1977New England Journal of Medicine, 1977
- Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology, 1975
- ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY WITH DYSPROTEINÆMIAThe Lancet, 1974
- A generalized Wilcoxon test for comparing arbitrarily singly-censored samplesBiometrika, 1965
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958