Δ 9 -Tetrahydrocannabinol: Aversive Effects in Rat at High Doses
- 25 February 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4024), 911-912
- https://doi.org/10.1126/science.175.4024.911
Abstract
Water-deprived rats were administered a single dose of Δ9-tetrahydrocannabinol either orally or intraperitoneally immediately after their first taste of a saccharine solution. In tests beginning 47 hours after drug administration, a dose-related reversal of rats' normal preference for saccharine was found. The data suggest that the drug produces aversive effects at doses of 1 to 32 milligrams per kilogram.Keywords
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