Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator.
Open Access
- 1 April 1978
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 147 (4), 1037-1043
- https://doi.org/10.1084/jem.147.4.1037
Abstract
J.H., an HLA-Dw2 homozygous multiparous woman, fails to respond to her husband, W.H. (HLA-D21) in the unidirectional mixed lymphocyte reaction. T [thymus derived] cells from J.H. suppress the responses of Dw2-positive cells but not Dw2-negative cells to W.H. A soluble factor released into the supernate of the mixed lymphocyte reaction by J.H. T cells mediates this suppression. Like the cell from which it is derived, the factor is highly specific for HLA Dw2 in the responder cell and partially specific for the stimulatory alloantigen.This publication has 17 references indexed in Scilit:
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