Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
- 17 August 1995
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 376 (6541), 572-575
- https://doi.org/10.1038/376572a0
Abstract
Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.Keywords
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