Tuberculostatic Action of Chloromycetin In vitro and In vivo.

Abstract

Chloromycetin has been found to be only moderately bacterio-static for virulent human type tubercle bacilli in vitro as compared with streptomycin or [rho]-aminosalicylic acid. The majority of 19 human type strains studied were completely inhibited in their growth by between 6.25 and 12.5 [gamma] or more of the drug in the presence of serum. One bovine strain was equally sensitive. This degree of bacteriostatic activity was not markedly affected by the no. of tubercle bacilli present nor was the bacteriostatic activity of [rho]-aminosalicylic acid or streptomycin enhanced by the addition of chloromycetin. When adm. subcut., chloromycetin is ineffective, whereas, when admixed with the diet in concns. of 0.25-0.5%, it was slightly effective for the suppression of exptl. murine tuberculosis.