Reduction of Absorption of Paracetamol by Activated Charcoal and Cholestyramine: A Possible Therapeutic Measure
- 14 July 1973
- Vol. 3 (5871), 86-87
- https://doi.org/10.1136/bmj.3.5871.86
Abstract
The absorption of an oral 2-g dose of paracetamol was markedly reduced by the simultaneous oral administration of either activated charcoal or cholestyramine but was only slightly reduced when the adsorbents were given 60 minutes after the paracetamol. Since the absorption of a larger dose of the drug will probably be slow, the administration of adsorbents may be of value even when delayed several hours.Keywords
This publication has 11 references indexed in Scilit:
- Pharmacological Modification of Gastric Emptying: Effects of Propantheline and Metoclopromide on Paracetamol AbsorptionBMJ, 1973
- The dependence of paracetamol absorption on the rate of gastric emptyingBritish Journal of Pharmacology, 1973
- HEPATIC DAMAGE AND DEATH FROM OVERDOSE OF PARACETAMOLThe Lancet, 1973
- Some factors affecting the absorption of paracetamolJournal of Pharmacy and Pharmacology, 1972
- Effect of activated charcoal on aspirin absorption in man Part IClinical Pharmacology & Therapeutics, 1972
- Absorption Kinetics of Aspirin in Man follow Oral Administration of an Aqueous SolutionJournal of Pharmaceutical Sciences, 1972
- Acute Paracetamol PoisoningBMJ, 1970
- The Absorption Characteristics of Paracetamol Tablets in ManJournal of Pharmacy and Pharmacology, 1963
- GASTROINTESTINAL PHARMACOLOGY OF ANTIPYRETIC-ANALGETIC AGENTS .2. ABSORPTION AND SMOOTH MUSCLE EFFECTS1959
- Plasma Levels After the Oral Administration of Acetylsalicylic Acid and N-Acetyl-P-Aminophenol in Different Forms to Human Subjects*Journal of the American Pharmaceutical Association (Scientific ed.), 1955