Hemodynamic Alterations in Hypertensive Patients Due to Chlorothiazide

Abstract

ONLY two studies have been published that detail the changes in cardiac output after chlorothiazide.^{1 , 2} Other reports^{3 , 4} have alluded to the changes in cardiac output without tabulating any data. In the studies in which results were reported in detail, cardiac output was performed by the dye-dilution technic. Aleksandrow and his co-workers¹ reported variable results in 7 hypertensive patients whereas Dustan and her associates² demonstrated a consistent decrease. This communication reports on a series of hypertensive patients in whom cardiac output was measured before and after administration of chlorothiazide. In the majority of patients the direct Fick method was used, the . . .