Renal Retention of Uric Acid Induced by Infusion of Beta-Hydroxybutyrate and Acetoacetate
- 18 February 1965
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 272 (7), 351-355
- https://doi.org/10.1056/nejm196502182720705
Abstract
HYPERURICEMIA has been observed in conjunction with a variety of metabolic aberrations, including starvation,1 2 3 4 obesity4 5 6 7 and diabetic ketoacidosis.8 The possibility that ketosis facilitates an increase in serum urate concentration by promoting renal retention of uric acid has been suggested in a number of reports.4,9 10 11 12 13 14 15 The purpose of the present study was to compare the influence of intravenously administered beta-hydroxybutyrate, acetoacetate and acetone on the renal clearance of uric acid in normal human subjects.Methods and MaterialsSodium acetoacetate was prepared by hydrolysis of freshly redistilled ethyl acetoacetate¶ with a 5 per cent excess of 1 N sodium hydroxide under . . .Keywords
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